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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOS2
All Species:
33.33
Human Site:
Y47
Identified Species:
73.33
UniProt:
Q07890
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07890
NP_008870.2
1332
152979
Y47
A
N
E
E
S
L
Y
Y
I
E
E
L
I
F
Q
Chimpanzee
Pan troglodytes
XP_515425
1598
179688
Y312
S
N
D
D
A
L
Q
Y
V
E
E
L
I
L
Q
Rhesus Macaque
Macaca mulatta
XP_001099864
1331
152695
Y47
A
N
E
E
S
L
Y
Y
I
E
E
L
I
F
Q
Dog
Lupus familis
XP_547804
1363
156214
Y78
A
N
E
E
S
L
Y
Y
I
E
E
L
I
F
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q02384
1333
153108
Y47
A
N
E
E
S
L
Y
Y
I
E
E
L
I
F
Q
Rat
Rattus norvegicus
NP_001129033
1333
153157
Y47
A
N
E
E
S
L
Y
Y
I
E
E
L
I
F
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515100
1332
152934
Y47
A
K
E
D
S
L
Y
Y
I
E
E
L
I
L
Q
Chicken
Gallus gallus
XP_421461
1466
167231
Y183
A
K
E
D
S
L
Y
Y
I
E
E
L
I
L
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_690171
1343
153249
L47
A
L
Q
H
I
E
A
L
I
L
Q
L
L
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26675
1596
177916
Y97
A
K
E
D
A
L
L
Y
V
E
K
L
C
L
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782335
1310
150821
L50
I
E
S
L
I
I
C
L
L
N
M
L
C
S
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.7
99
93.2
N.A.
94.9
94.6
N.A.
91.1
78.9
N.A.
73
N.A.
39.8
N.A.
N.A.
52.1
Protein Similarity:
100
68.5
99.7
95.5
N.A.
97.9
97.4
N.A.
95.9
84.7
N.A.
83.9
N.A.
55.1
N.A.
N.A.
68
P-Site Identity:
100
53.3
100
100
N.A.
100
100
N.A.
80
80
N.A.
20
N.A.
40
N.A.
N.A.
6.6
P-Site Similarity:
100
86.6
100
100
N.A.
100
100
N.A.
86.6
86.6
N.A.
46.6
N.A.
73.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
82
0
0
0
19
0
10
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
0
19
0
0
% C
% Asp:
0
0
10
37
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
73
46
0
10
0
0
0
82
73
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
46
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
19
10
0
0
73
0
0
0
73
0
0
% I
% Lys:
0
28
0
0
0
0
0
0
0
0
10
0
0
0
10
% K
% Leu:
0
10
0
10
0
82
10
19
10
10
0
100
10
37
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
55
0
0
0
0
0
0
0
10
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
10
0
0
0
10
0
0
0
73
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
10
0
10
0
64
0
0
0
0
0
0
0
0
10
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
19
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
64
82
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _